Definitions:

1. Means to laugh loudly, boisterously, or uncontrollably. VERB
   • The comedian's joke mede the entire audience cachinnate with delight.
2. Refers to a form of laughter that is often intense, hearty, and unrestrained. VERB
   • He couldn't help but cachinnate at the absurdity of the situation.

Synonyms:

• belly laugh
• guffaw
• howl with laughter
• roar