What is the meaning of the word "irritate"?

Definitions:

  1. excite to an abnormal condition, or chafe or inflame copy to clipboard verb
    • Aspirin irritates my stomach copy to clipboard
  2. excite to some characteristic action or condition, such as motion, contraction, or nervous impulse, by the application of a stimulus copy to clipboard verb
    • irritate the glands of a leaf copy to clipboard

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